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1.
Artigo em Inglês | MEDLINE | ID: mdl-38083739

RESUMO

A lab-on-a-chip multichannel sensing platform for biomedical analysis based on optical silicon nitride (SiNx) microring-resonators (MRR) was established. The resonators were surface functionalized and finally combined with a microfluidic chamber for validation using an avidin-biotin ligand-binding assay. The results with a limit of detection (LOD) of 2.3∙10-5 and a mean intra-assay coefficient of variation (CV) of ±10.0 %, also under consideration of FDA guidelines, show promising future applicability for a wide variety of targets in the field of outpatient medical diagnostics and life science.Clinical Relevance- Biomarkers play a crucial role in physiological processes of the human body. To enable instantaneous and decentralized analysis of these markers, systems are needed that can be used in a laboratory-independent environment with minimal amounts of biofluid. An example is the utilization of such systems for neonates or infants.


Assuntos
Técnicas Biossensoriais , Óptica e Fotônica , Recém-Nascido , Humanos , Técnicas Biossensoriais/métodos , Fótons , Compostos de Silício
2.
Opt Express ; 30(25): 44701-44716, 2022 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-36522889

RESUMO

For wireless networks beyond 5G, directivity and reconfigurability of antennas are highly relevant. Therefore, we propose a linear antenna array based on photodiodes operating at 300 GHz, and an optical phased array based on polymer waveguides to orchestrate the antennas. Due to its low thermal conductivity and high thermo-optical coefficient, the polymer chip enables highly efficient and crosstalk-free phase shifting. With these, we demonstrate purely photonic-controlled beam steering across 20°. Compared to a single emitter, the 3-dB beam width is reduced by 8.5° to 22.5° and the output power is >10 dB higher. Employing Snell's law for coupling into air, we can precisely predict the radiation patterns.

3.
Biosensors (Basel) ; 9(1)2019 Feb 12.
Artigo em Inglês | MEDLINE | ID: mdl-30759839

RESUMO

We fabricated a simple sensor system for qualitative analysis of glycan-mediated interactions. Our main aim was to establish a ronbbust system that allowes drop-tests without complex fluidics. The test system should be usable in routine analytics in the future and bear sufficient sensitivity to detect binding events in the nanomolar range. For this, we employed optical ring resonators and coated them with high avidity glycopolymers based on N-acetylglucosamine (GlcNAc). These hydrophilic polymers are also very feasible in preventing unspecific protein adsorption. Drop-on binding studies with suitable lectins showed that glycopolymers were specifically recognized by a lectin with GlcNAc-specificity and prevented unspecific protein interactions very well. The system could be elaborated in the future for detection of glycan-mediated interactions in the biomedical field and is promising in means of multiplexed analysis and usage in routine analysis.


Assuntos
Acetilglucosamina/química , Lectinas/metabolismo , Fenômenos Ópticos , Polímeros/química , Espectroscopia Fotoeletrônica , Ligação Proteica
4.
Sci Rep ; 8(1): 3018, 2018 02 14.
Artigo em Inglês | MEDLINE | ID: mdl-29445213

RESUMO

We report for the first time the successful wavelength stabilization of two hybrid integrated InP/Polymer DBR lasers through optical injection. The two InP/Polymer DBR lasers are integrated into a photonic integrated circuit, providing an ideal source for millimeter and Terahertz wave generation by optical heterodyne technique. These lasers offer the widest tuning range of the carrier wave demonstrated to date up into the Terahertz range, about 20 nm (2.5 THz) on a single photonic integrated circuit. We demonstrate the application of this source to generate a carrier wave at 330 GHz to establish a wireless data transmission link at a data rate up to 18 Gbit/s. Using a coherent detection scheme we increase the sensitivity by more than 10 dB over direct detection.

5.
Opt Lett ; 40(4): 447-50, 2015 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-25680121

RESUMO

An external cavity laser is demonstrated based on the hybrid integration of an InP-based gain element, a half-wave plate, and thermally drivable polymer waveguide circuits. The laser has one oscillation region but two outputs for TE and TM emissions. The central wavelength can be tuned 20 nm at 20 mW heater electrical power. The TM path undergoes a 1.4 dB power penalty due to the presence of the half-wave plate. However, the on-chip thermo-optic switch (TOS) can compensate for this imbalance and steer the laser into an equal TE and TM output power. The TOS can also be adjusted to prefer one polarization path over the other with ∼10 dB extinction ratio.

6.
Opt Lett ; 39(17): 5170-2, 2014 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-25166101

RESUMO

An optical filter based on all-polymer grating-assisted directional coupler is demonstrated. The wavelength tuning is differentially driven. The heater-electrodes created on the sidewalls of the polymer ridge can either blue- or red-shift the central wavelength. A total tuning range of 301 nm is achieved experimentally. The maximal local temperature gradient introduced across the coupler region is only 55°C-68°C. The filter is also insensitive to uniform ambient temperature change. Central wavelength jitter of ±3 nm is observed when the chip holder temperature cycles between 20°C and 80°C.

7.
Opt Lett ; 39(1): 162-5, 2014 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-24365848

RESUMO

A grating-assisted heterogeneous waveguide coupler is designed, fabricated, and demonstrated on a polymer platform. The parallel silicon nitrite core and polymer core are horizontally placed with vertical center alignment accuracy of ±5 nm. The coupler is differentially thermally tunable. The temperature gradient distribution, introduced by offset micro-heaters, is studied by thermal simulations. A total tuning range of 82 nm is demonstrated experimentally.

8.
Opt Express ; 20(27): 28538-43, 2012 Dec 17.
Artigo em Inglês | MEDLINE | ID: mdl-23263091

RESUMO

We demonstrate the first integrated transmitter for serial 100 Gb/s NRZ-OOK modulation in datacom and telecom applications. The transmitter relies on the use of an electro-optic polymer modulator and the hybrid integration of an InP laser diode and InP-DHBT electronics with the polymer board. Evaluation is made at 80 and 100 Gb/s through eye-diagrams and BER measurements using a receiver module that integrates a pin-photodiode and an electrical 1:2 demultiplexer. Error-free performance is confirmed both at 80 and 100 Gb/s revealing the viability of the approach and the potential of the technology.


Assuntos
Redes de Comunicação de Computadores/instrumentação , Índio/química , Lasers Semicondutores , Fosfinas/química , Semicondutores , Telecomunicações/instrumentação , Triptaminas/química , Desenho de Equipamento , Análise de Falha de Equipamento , Micro-Ondas , Fótons
9.
Opt Express ; 19(13): 12197-207, 2011 Jun 20.
Artigo em Inglês | MEDLINE | ID: mdl-21716457

RESUMO

We report a direct DPSK receiver based on polymer planar lightwave circuit technology, which incorporates a 2x25 GHz photodiode (PD) array hybridly integrated via 45° mirrors. In this direct DPSK receiver, a half-wave plate and heating electrodes are implemented to eliminate the polarization-dependent frequency-shift (PDFS) of the delay-line interferometer (DLI). By applying a proper heating current, a residual PDFS of practically zero at 1550 nm and within ±125 MHz was achieved over the full C-band. Integrated with the PD array, the peak responsivity is ~0.14 A/W for orthogonal polarizations over the C-band. To characterize this direct receiver, we introduce an adapted common-mode rejection ratio (CMRR), which takes into account the unequal responsivities of the PDs, the uneven split of the input power by the DLI, the phase error and the extinction ratio of the DLI. The measured CMRR under DC condition is below -20 dB over the C-band.


Assuntos
Interferometria/instrumentação , Luz , Medições Luminescentes/instrumentação , Polímeros/química , Processamento de Sinais Assistido por Computador/instrumentação , Birrefringência , Impedância Elétrica , Modelos Teóricos
10.
Opt Express ; 19(26): B166-72, 2011 Dec 12.
Artigo em Inglês | MEDLINE | ID: mdl-22274014

RESUMO

A dual-quadrature coherent receiver based on a polymer planar lightwave circuit (PLC) is presented. This receiver comprises two separate optical 90°-hybrid chips made of polymer waveguides and hybridly integrated with InGaAs/InP photodiode (PD) arrays. The packaged receiver was successfully operated in 112 Gbit/s dual-polarization quadrature phase-shift keying (QPSK) transmission experiments. In back-to-back configuration the OSNR requirement for a BER value of 10(-3) was 15.1 dB which has to be compared to a theoretical limit of 13.8 dB.

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